Buster Bunny's mission in this game is to trace down and defeat Montana Max, who has stolen and hidden some treasure and rescue Babs Bunny. Besides, he has to find the treasure stolen by Doctor Jim. Unlike in the previous game version, in this one the rabbit’s friends don’t assist him throughout the game. Many of foes are in the way, including Roderick Rat and Gene Splicer, who has brainwashed several of Buster's friends, including Plucky Duck, Hamton J. Pig, Dizzy Devil and Calamity Coyote. Upon defeating Gene, the helmet controlling Buster's friends will fall off and explode, leaving them dazed or to fall down in a comical fashion (in the case of Calamity Coyote).