Measles virus Replication Outline: Measles viruscontains negative stranded RNA and is 150-300 nm in diameter. On its surface it has two membrane proteins - Fusion protein and Hemagglutinin. Hemagglutinin binds to the receptor on the host cell membrane. Here only Hemagglutinin is shown, for a more detailed viral structure see the Morbilivirus After the virus binds to the host membrane, the viral plasma membrane fuses with the host membrane with the help of the Fusion protein. Then ribonucleocapsid is released into the cytoplasm. In the host cell the sequential transcription takes place, viral mRNAs are capped and polyadenylated in the cytoplasm. In this scene only the formation of the viral membrane protein is shown, viral mRNA codes also other proteins, including the nucleoprotein. When enough nucleoprotein has been formed, starts the replication of the viral genome.
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