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Mesothelioma Symptoms: Asbestos Cancer Warning Signs What Are the Most Common Mesothelioma Symptoms? The first symptoms of mesothelioma include chest or abdominal pain, bloating and shortness of breath, depending on the location of the cancer. Because early-stage signs can be slight, doctors often mistake them as normal aches and pains or symptoms of less serious illnesses. Mesothelioma tumors begin as tiny nodules on the lining of the lungs or abdomen. The cancer doesn’t cause symptoms until the tumors have grown and spread. This is usually around cancer stage 3 and 4, when tumors begin to press against the chest wall or abdominal cavity. Recognizing symptoms of mesothelioma early in the cancer’s development is nearly impossible because the disease doesn’t produce early symptoms to identify.