Epazote is an herb native to Central America, South America, and southern Mexico.Epazote is a popular Central American herb used by native Mexicans since antiquity. Its strong, musky flavor gives unique taste to Mexican and other Latin American cuisines. While its young shoots and tender leaves used like leafy greens in soups; its mature, pungent leaves employed in small quantities as digestive and carminatives in bean, fish, and corn dishes.