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With medication and lifestyle changes, though, plaques may slow or stop growing. They may even shrink slightly with aggressive treatment. Lifestyle changes Reducing the lifestyle risk factors that lead to atherosclerosis will slow or stop the process. That means a healthy diet, exercise, and no smoking. Treatments for atherosclerosis may include lifestyle changes, medicines, and medical procedures or surgery. The goals of treatment include: Relieving symptoms. Reducing risk factors in an effort to slow or stop the buildup of plaque.